Open AccessNon-IFNγ Whole Blood Cytokine Responses to Mycobacterium tuberculosis Antigens in HIV-exposed Infants
Author(s) -
Christine Anterasian,
Alex J Warr,
Sylvia M LaCourse,
John Kinuthia,
Barbra A. Richardson,
Felicia K. Nguyen,
Daniel Matemo,
Elizabeth MalecheObimbo,
Grace C. John-. Stewart,
Thomas R. Hawn
Publication year - 2021
Publication title -
the pediatric infectious disease journal/the pediatric infectious disease journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 140
eISSN - 1532-0987
pISSN - 0891-3668
DOI - 10.1097/inf.0000000000003254
Subject(s) - immunology , medicine , tuberculin , tuberculosis , mycobacterium tuberculosis , antigen , quantiferon , cytokine , virology , latent tuberculosis , pathology
HIV-exposed uninfected (HEU) infants have increased risk of tuberculosis (TB). Testing for Mycobacterium tuberculosis (Mtb) infection is limited by reduced Quantiferon (QFT) sensitivity in infants and tuberculin skin test (TST) cross-reactivity with Bacillus Calmette-Guérin vaccine. Our objective is to assess if non-IFNγ cytokine responses to Mtb-specific antigens have improved sensitivity in detecting Mtb infection in HEU infants compared with QFT.