Open AccessImpact of Anaerobic Antibacterial Spectrum on Cystic Fibrosis Airway Microbiome Diversity and Pulmonary Function
Author(s) -
Michael J. Bozzella,
Hollis Chaney,
Iman Sami,
Anastassios C. Koumbourlis,
James E. Bost,
Edith T. Zemanick,
Robert J. Freishtat,
Keith A. Crandall,
Andrea Hahn
Publication year - 2021
Publication title -
the pediatric infectious disease journal/the pediatric infectious disease journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 140
eISSN - 1532-0987
pISSN - 0891-3668
DOI - 10.1097/inf.0000000000003211
Subject(s) - cystic fibrosis , anaerobic exercise , medicine , pulmonary function testing , antibiotics , microbiome , lung , microbiology and biotechnology , biology , physiology , bioinformatics
The role of anaerobic organisms in the cystic fibrosis (CF) lung microbiome is unclear. Our objectives were to investigate the effect of broad (BS) versus narrow (NS) spectrum antianaerobic antibiotic activity on lung microbiome diversity and pulmonary function, hypothesizing that BS antibiotics would cause greater change in microbiome diversity without a significant improvement in lung function.