Open AccessQuantiFERON-TB Gold Plus Assay Specificity in Children and Adolescents With Suspected Tuberculosis—A Multicenter Cross-sectional Study in Spain
Author(s) -
Aleix Soler-García,
Anna Gamell,
Begoña Santiago,
Manuel Monsonís,
Elvira Cobo-Vázquez,
Matilde Bustillo-Alonso,
Alfredo Tagarro,
Beatriz Pérez-Gorricho,
María Espiau,
Ana Isabel Piqueras,
Javier Korta-Murúa,
Paula Rodríguez-Molino,
Zulema Lobato,
Tomàs Pérez-Porcuna,
Marc Tebruegge,
Antoni Noguera-Julián
Publication year - 2021
Publication title -
the pediatric infectious disease journal/the pediatric infectious disease journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 140
eISSN - 1532-0987
pISSN - 0891-3668
DOI - 10.1097/inf.0000000000003173
Subject(s) - medicine , tuberculin , gold standard (test) , tuberculosis , predictive value , cross sectional study , quantiferon , multicenter study , predictive value of tests , interferon gamma release assay , interferon γ , interferon gamma , immunology , mycobacterium tuberculosis , pathology , latent tuberculosis , randomized controlled trial , cytokine
In this cross-sectional study of 284 children and adolescents with clinically or radiologically suspected tuberculosis in a low-endemic country, the QuantiFERON-TB Gold Plus assay specificity, sensitivity, positive predictive value and negative predictive value were 91.5%, 87.3%, 86.4%, and 91.2%, respectively. The specificity was higher than that observed in tuberculin skin tests performed simultaneously, but similar to previous-generation interferon-gamma release assays.