Open AccessEvaluation of a Novel Culture System for Rapid Pathogen Identification and Detection of Cephalosporin Resistance in Neonatal Gram-negative Sepsis at a Tertiary Referral Unit in Harare, Zimbabwe
Author(s) -
Gwendoline Chimhini,
Ioana D. Olaru,
Felicity Fitzgerald,
Mutsawashe Chisenga,
Cecilia Ferreyra,
Nada Malou,
Jérémie Piton,
Simbarashe Chimhuya,
Shunmay Yeung,
Surya K. De,
Hilda Mujuru,
Katharina Kranzer
Publication year - 2021
Publication title -
the pediatric infectious disease journal/the pediatric infectious disease journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 140
eISSN - 1532-0987
pISSN - 0891-3668
DOI - 10.1097/inf.0000000000003155
Subject(s) - blood culture , medicine , neonatal sepsis , sepsis , ceftriaxone , interquartile range , gram staining , klebsiella pneumoniae , gentamicin , cephalosporin , neonatal intensive care unit , microbiology and biotechnology , pediatrics , antibiotics , biology , biochemistry , escherichia coli , gene
Neonatal sepsis accounts for a large proportion of neonatal deaths in sub-Saharan Africa. The lack of access to diagnostic testing and excessively long turnaround times to result contributes to delays in sepsis identification and initiation of appropriate treatment. This study aims to evaluate the novel InTrays COLOREX Screen and extended-spectrum beta-lactamase for rapid identification of bacterial pathogens causing sepsis and detection of resistance.