Open AccessFirst Report of SARS-CoV-2 Detection in Cerebrospinal Fluid in a Child With Guillain-Barré Syndrome
Author(s) -
Naiana Mota Araújo,
Lis Campos Ferreira,
Débora Paraíso Dantas,
Denison Santos Silva,
Cliomar Alves dos Santos,
Rosana Cipolotti,
Paulo Ricardo MartinsFilho
Publication year - 2021
Publication title -
the pediatric infectious disease journal/the pediatric infectious disease journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 140
eISSN - 1532-0987
pISSN - 0891-3668
DOI - 10.1097/inf.0000000000003146
Subject(s) - guillain barre syndrome , cerebrospinal fluid , medicine , covid-19 , immune system , immunology , betacoronavirus , coronavirus , inflammation , virology , pathology , disease , outbreak , infectious disease (medical specialty)
Underlying mechanisms on the association between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and neurologic complications are still poorly understood. Cases of Guillain-Barré Syndrome (GBS) have been linked to the SARS-CoV-2 infection as the result of dysregulated immune response with damage in neuronal tissues. In the current report, we present the first pediatric case of GBS with detection of SARS-CoV-2 in the cerebrospinal fluid (CFS). This unique case of COVID-19-associated GBS with detection of SARS-CoV-2 RNA in the CSF indicates direct viral involvement inducing peripheral nerve inflammation.