Open AccessOutcomes of Children Born to Pregnant Women With Drug-resistant Tuberculosis Treated With Novel Drugs in Khayelitsha, South Africa: A Report of Five Patients
Author(s) -
Ronald Acquah,
Erika Mohr,
Johnny Daniels,
Jennifer Furin,
Marian Loveday,
Vanessa Mudaly,
Anja Reuter
Publication year - 2021
Publication title -
the pediatric infectious disease journal/the pediatric infectious disease journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 140
eISSN - 1532-0987
pISSN - 0891-3668
DOI - 10.1097/inf.0000000000003069
Subject(s) - bedaquiline , medicine , regimen , tuberculosis , rifampicin , drug resistant tuberculosis , linezolid , drug , pediatrics , obstetrics , pharmacology , mycobacterium tuberculosis , pathology , vancomycin , biology , bacteria , genetics , staphylococcus aureus
This brief report presents a series of 5 pregnant women treated for rifampicin-resistant tuberculosis with the novel drugs bedaquiline, delamanid, and linezolid as part of an optimized backbone regimen and reviews the outcomes of the children born to them. Although the case series is small, all children had excellent birth outcomes suggesting pregnant women should not be denied access to novel therapies for RR-TB.