Open AccessPediatric Community-Acquired Bone and Joint Staphylococcus Aureus Infections In Europe
Author(s) -
Manuel Gijón,
Marcello Bellusci,
Birutė Petraitienė,
Antoni NogueraJulian,
Daniel Glikman,
Jesús Saavedra-Lozano,
Olaf Neth,
Maria Daskalaki,
Virginija Žilinskaitė,
Petra Kaiser-Labusch,
Luís Prieto,
Pablo Rojo
Publication year - 2020
Publication title -
the pediatric infectious disease journal/the pediatric infectious disease journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 140
eISSN - 1532-0987
pISSN - 0891-3668
DOI - 10.1097/inf.0000000000002640
Subject(s) - panton–valentine leukocidin , staphylococcus aureus , leukocidin , medicine , odds ratio , cohort , methicillin resistant staphylococcus aureus , joint infections , pathogen , microbiology and biotechnology , immunology , biology , surgery , bacteria , genetics , periprosthetic , arthroplasty
To analyze host and pathogen factors related to disease severity of community-acquired bone and joint infections in children, a cohort of pediatric patients was prospectively recruited from 13 centers in 7 European countries. A total of 85 children were included, 11 (13%) had a severe infection. Panton-Valentine leukocidin-positive isolates were 17%, and 6% of the isolates were methicillin-resistant Staphylococcus aureus. Multivariate analysis identified Panton-Valentine leukocidin presence (adjusted odds ratio, 12.6; P = 0.01) as the only factor independently associated with severe outcome, regardless of methicillin resistance.