Open AccessInfluenza or Meningococcal Immunization During Pregnancy and Mortality in Women and Infants
Author(s) -
Dayna R Clark,
Saad B. Omer,
Milagritos D. Tapia,
Marta C Nunes,
Clare Cutland,
James M. Tielsch,
Niteen Wairagkar,
Shabir A. Madhi
Publication year - 2020
Publication title -
the pediatric infectious disease journal/the pediatric infectious disease journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 140
eISSN - 1532-0987
pISSN - 0891-3668
DOI - 10.1097/inf.0000000000002629
Subject(s) - medicine , immunization , pregnancy , meningococcal vaccine , obstetrics , meningococcal disease , pediatrics , neisseria meningitidis , immunology , antibody , biology , genetics , bacteria
This analysis includes pooled data from 2 placebo-controlled maternal influenza immunization trials, with a separate analysis on a meningococcal conjugate vaccine-controlled maternal influenza immunization trial. Maternal influenza immunization was not associated with infant or maternal all-cause mortality in placebo-controlled trials. In the meningococcal conjugate vaccine-controlled trial, there were fewer deaths during low or any influenza circulation weeks among infants whose mothers received meningococcal conjugate vaccine. ClinicalTrials.gov identifiers: NCT01430689, NCT01034254 and NCT02465190.