Open AccessSimulated Comparison of a Bayesian Clinical Decision Support System Versus Standard of Care For Achieving Gentamicin Pharmacokinetic Targets in Neonates
Author(s) -
Collin Z. Yu,
Scott R Myers,
Jonathan D. Faldasz
Publication year - 2020
Publication title -
the pediatric infectious disease journal/the pediatric infectious disease journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 140
eISSN - 1532-0987
pISSN - 0891-3668
DOI - 10.1097/inf.0000000000002592
Subject(s) - dosing , medicine , nomogram , pharmacokinetics , therapeutic drug monitoring , trough concentration , trough level , gentamicin , antibiotics , chemistry , transplantation , biochemistry , tacrolimus
Gentamicin therapy in neonates is optimized through achieving specific peak and trough concentrations. The objective of this study was to compare the ability a Bayesian clinical decision support system (CDSS) with standard of care (SOC) in determining personalized gentamicin therapies for neonates, at regimen initiation and in response to measured drug concentrations.