Open AccessEnteropathogens and Rotavirus Vaccine Immunogenicity in a Cluster Randomized Trial of Improved Water, Sanitation and Hygiene in Rural Zimbabwe
Author(s) -
James Church,
Elizabeth T Rogawski McQuade,
Kuda Mutasa,
Mami Taniuchi,
Sandra Rukobo,
Margaret Govha,
Benjamin Lee,
Marya P. Carmolli,
Bernard Chasekwa,
Robert Ntozini,
Monica McNeal,
Lawrence H. Moulton,
Beth D. Kirkpatrick,
Jie Liu,
Eric R. Houpt,
Jean H. Humphrey,
James A Platts-Mills,
Andrew J. Prendergast
Publication year - 2019
Publication title -
the pediatric infectious disease journal/the pediatric infectious disease journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 140
eISSN - 1532-0987
pISSN - 0891-3668
DOI - 10.1097/inf.0000000000002485
Subject(s) - seroconversion , rotavirus , immunogenicity , medicine , confidence interval , enterovirus , relative risk , rotavirus vaccine , reoviridae , virology , immunology , antibody , virus
Oral rotavirus vaccines (RVVs) are less efficacious in low-income versus high-income settings, plausibly due to more enteropathogen exposure through poor water, sanitation and hygiene (WASH). We explored associations between enteropathogens and RVV immunogenicity and evaluated the effect of improved WASH on enteropathogen carriage.