Open AccessRoute of Oseltamivir Administration Affects Metabolite Concentrations in Critically Ill Children
Author(s) -
Sonya Tang Girdwood,
Tomoyuki Mizuno,
Kelli A. Krallman,
Laura Benken,
Erin Stoneman,
Toni Yunger,
Hector R. Wong,
Alexander A. Vinks,
Jennifer Kaplan
Publication year - 2019
Publication title -
the pediatric infectious disease journal/the pediatric infectious disease journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 140
eISSN - 1532-0987
pISSN - 0891-3668
DOI - 10.1097/inf.0000000000002473
Subject(s) - metabolite , oseltamivir , critically ill , active metabolite , medicine , prospective cohort study , administration (probate law) , pharmacology , critical illness , oral administration , route of administration , cohort study , anesthesia , intensive care medicine , covid-19 , disease , political science , infectious disease (medical specialty) , law
We performed a prospective cohort study to investigate oseltamivir administration in critically ill children. We found that enteric tube administration of oseltamivir resulted in lower concentrations of its active metabolite compared with oral delivery. These findings could have significant clinical implications, and more studies are required to better understand the effects of administration route on potential lower systemic metabolite exposure.