Open AccessBorderline-Positive Quantiferon in Children
Author(s) -
Ulrikka Nygaard,
Anja Poulsen,
Alex Christian Yde Nielsen,
Pernille Ravn,
Nadja Hawwa Vissing
Publication year - 2019
Publication title -
the pediatric infectious disease journal/the pediatric infectious disease journal
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 140
eISSN - 1532-0987
pISSN - 0891-3668
DOI - 10.1097/inf.0000000000002416
Subject(s) - quantiferon , psychology , medicine , tuberculosis , pathology , latent tuberculosis , mycobacterium tuberculosis
We systematically retested children with borderline-positive quantiferon (0.35-0.99 IU/mL) during the period 2015-2019. Among 647 tests, 27 (4%) were positive (>0.35 IU/mL). Borderline-positive quantiferon accounted for 10 of 27 (37%) positive tests. When retested, 9 of 10 (90%) were negative. Children younger than 5 years had negative tuberculin skin tests. Thus, we found high test variability in the borderline range and, in some children, high suspicion of false positive tests.