Open AccessIn Utero Efavirenz Exposure and Neurodevelopmental Outcomes in HIV-exposed Uninfected Children in Botswana
Author(s) -
Adam R. Cassidy,
Paige L. Williams,
Jean Leidner,
Gloria Mayondi,
Gbolahan Ajibola,
Joseph Makhema,
Penny Holding,
Kathleen M. Powis,
Oganne Batlang,
Chipo Petlo,
Roger Shapiro,
Betsy Kammerer,
Shahin Lockman
Publication year - 2019
Publication title -
the pediatric infectious disease journal/the pediatric infectious disease journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 140
eISSN - 1532-0987
pISSN - 0891-3668
DOI - 10.1097/inf.0000000000002332
Subject(s) - bayley scales of infant development , toddler , efavirenz , in utero , medicine , pediatrics , cohort , human immunodeficiency virus (hiv) , pregnancy , psychology , viral load , antiretroviral therapy , psychiatry , developmental psychology , fetus , immunology , biology , cognition , genetics , psychomotor learning
Minimal data exist related to neurodevelopment after in utero exposure to Efavirenz (EFV). We sought to compare neurodevelopmental outcomes in HIV-exposed/uninfected (HEU) children with in utero exposure to EFV-based triple antiretroviral treatment (ART) versus non-EFV-based ART, and to examine whether timing of initial EFV exposure is associated with neurodevelopment deficits.