Open AccessTwo Randomized Trials of the Effect of the Russian Strain of Bacillus Calmette-Guérin Alone or With Oral Polio Vaccine on Neonatal Mortality in Infants Weighing <2000 g in India
Author(s) -
J. Kumutha,
B Adhisivam,
Saravanan Nallasivan,
R Gokul Krishnan,
Chinnathambi Kamalarathnam,
M. Bharathi,
Brian P. McSharry,
Siva P. Namachivayam,
Frank Shann,
Sasireka I Boopalan,
Ponrani David,
B. Vishnu Bhat
Publication year - 2019
Publication title -
the pediatric infectious disease journal/the pediatric infectious disease journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 140
eISSN - 1532-0987
pISSN - 0891-3668
DOI - 10.1097/inf.0000000000002198
Subject(s) - medicine , hazard ratio , randomized controlled trial , confidence interval , poliomyelitis , pediatrics , bcg vaccine , pneumonia , vaccination , immunology
In randomized trials in Guinea-Bissau, the Danish strain of Bacillus Calmette-Guérin (BCG) reduces neonatal mortality, primarily by reducing deaths from pneumonia and sepsis. Because World Health Organization-prequalified BCG-Denmark was not available in India, we conducted 2 randomized trials to test whether BCG-Russia alone or with oral polio vaccine (OPV) has similar effects to BCG-Denmark.