Open AccessAccuracy of Xpert Mtb/Rif Ultra for the Diagnosis of Pulmonary Tuberculosis in Children
Author(s) -
Mark P. Nicol,
Lesley Workman,
Margaretha Prins,
Lindy Bateman,
Yonas Ghebrekristos,
Silindile Mbhele,
Claudia M. Denkinger,
Heather J. Zar
Publication year - 2018
Publication title -
the pediatric infectious disease journal/the pediatric infectious disease journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 140
eISSN - 1532-0987
pISSN - 0891-3668
DOI - 10.1097/inf.0000000000001960
Subject(s) - pulmonary tuberculosis , medicine , sputum , tuberculosis , sputum culture , mycobacterium tuberculosis , virology , pathology
We determined the accuracy of the new Xpert MTB/RIF Ultra assay for diagnosis of pulmonary tuberculosis in children, using banked-induced sputum. Sensitivity and specificity were 75.3% and 96.9%, respectively, compared with a culture result from the same specimen. Of those children with microbiologically confirmed tuberculosis (positive Xpert, Ultra or culture), Xpert detected 63.2%, Ultra 73.7% and culture 82.9%.