Open AccessBone Formation Using Cross-Linked Chitosan Scaffolds in Rat Calvarial Defects
Author(s) -
Chang-Kai Chen,
Nai-Jen Chang,
Yung-Tsan Wu,
Earl Fu,
EChin Shen,
Chien-Wei Feng,
ZhiHong Wen
Publication year - 2018
Publication title -
implant dentistry
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.538
H-Index - 65
eISSN - 1538-2982
pISSN - 1056-6163
DOI - 10.1097/id.0000000000000670
Subject(s) - chitosan , chemistry , dentistry , medicine , biochemistry
To investigate the osteoconductive effect of a chitosan scaffold in a rat skull defect model. Previous publications have demonstrated the osteoinductive properties as scaffold materials with growth factors; however, whether chitosan alone has osteoconductive ability is unclear. This study used cross-linked chitosan scaffolds for in vivo evaluation of scaffold-supported bone regeneration in rat calvarial defects using histopathological analysis and examination of alkaline phosphatase (ALP), calcium, phosphorus, and calcitonin serum levels.