Open AccessOcular Clinical Signs and Diagnostic Tests Most Compatible With Keratoconjunctivitis Sicca: A Latent Class Approach
Author(s) -
John A. Gonzales,
Stephen Shiboski,
Vatinee Y. Bunya,
Esen Karamürsel Akpek,
Jennifer RoseNussbaumer,
Gerami D. Seitzman,
Lindsey A. Criswell,
Caroline H. Shiboski,
Thomas M. Lietman
Publication year - 2020
Publication title -
cornea
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.274
H-Index - 117
eISSN - 1536-4798
pISSN - 0277-3740
DOI - 10.1097/ico.0000000000002311
Subject(s) - keratoconjunctivitis sicca , gold standard (test) , medicine , schirmer test , gastroenterology , ophthalmology , saliva , tears , pathology , dermatology , dry eyes , surgery
Purpose: To evaluate the ocular signs and tests for keratoconjunctivitis sicca (KCS) in the absence of a gold standard. Methods: Cross-sectional study of participants from the Sjögren’s International Collaborative Clinical Alliance (SICCA) registry. Participants had oral/ocular/rheumatologic examinations, blood/ saliva samples collected, and salivary gland biopsy. Latent class analysis (LCA) identified clusters of patients based on 3 to 4 predictor variables relating to signs or tests of KCS. The resulting model-based “gold standard” classification formed the basis for estimated sensitivity and specificity associated with these predictors. Results: A total of 3514 participants were enrolled into SICCA, with 52.9% classified as SS. LCA revealed a best-fit model with 2 groups. For the gold standard–positive group, an abnormal tear breakup time, ocular staining score (OSS), and Schirmer I had a sensitivity of 99.5%, 91.0%, and 47.4%, respectively. For the gold standard–negative group, an abnormal tear breakup time, OSS, and Schirmer I had a specificity of 32.0%, 84.0%, and 88.5%, respectively. OSS components (fluorescein and lissamine staining), exhibited a sensitivity of 82.6% and 90.5%, respectively, in the gold standard–positive group, whereas these signs in the gold standard–negative group had a specificity of 88.8% and 73.0%, respectively. Conclusions: OSS and its components (fluorescein and lissamine staining) differentiated 2 groups from each other better than other KCS parameters and had relatively high sensitivity and specificity.