Open AccessTear Levels of IGFBP-3: A Potential Biomarker for Diabetic Nerve Changes in the Cornea
Author(s) -
Whitney Stuard,
Rossella Titone,
Danielle M. Robertson
Publication year - 2020
Publication title -
eye and contact lens
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.781
H-Index - 57
eISSN - 1542-233X
pISSN - 1542-2321
DOI - 10.1097/icl.0000000000000700
Subject(s) - medicine , diabetes mellitus , nerve plexus , cornea , biomarker , diabetic retinopathy , ophthalmology , type 2 diabetes , disease , corneal diseases , pathology , endocrinology , biology , biochemistry
Type 2 diabetes mellitus has reached epidemic levels in the United States and worldwide. Ocular complications from this disease include diabetic retinopathy and keratopathy, both of which can lead to significant vision loss. While frequently underappreciated, diabetic keratopathy is associated with painful ocular surface disorders, including corneal erosions and delayed wound healing. Recent work in our laboratory has focused on the role of the insulin-like growth factor (IGF) system in diabetic corneal disease.