Open AccessRabbit Fungal Keratitis Model of Fusarium solani Tested Against Three Commercially Available Antifungal Drugs
Author(s) -
Thet Tun Aung,
Wei Hong Jeff Chor,
Myoe Naing Lynn,
Anita Chan,
Donald Tan,
Roger W. Beuerman
Publication year - 2020
Publication title -
eye and contact lens
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.781
H-Index - 57
eISSN - 1542-233X
pISSN - 1542-2321
DOI - 10.1097/icl.0000000000000689
Subject(s) - fungal keratitis , voriconazole , fusarium solani , natamycin , keratitis , amphotericin b , scedosporium apiospermum , microbiology and biotechnology , histopathology , medicine , biology , antifungal , pathology , dermatology
The purpose of this study was to develop a reproducible preclinical Fusarium solani keratitis model, which would allow comparative testing of currently available antifungals (NATACYN [Alcon, Fort Worth, TX], voriconazole 1%, and amphotericin B 0.1%) as well as efficacy testing of new antifungals for translation into clinical practice in the future.