Open AccessMetabolic Regulation of Hematopoietic Stem Cells
Author(s) -
Morganti Claudia,
CabezasWallscheid Nina,
Ito Keisuke
Publication year - 2022
Publication title -
hemasphere
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 11
ISSN - 2572-9241
DOI - 10.1097/hs9.0000000000000740
Subject(s) - citric acid cycle , oxidative phosphorylation , glycolysis , microbiology and biotechnology , mitochondrion , biology , haematopoiesis , stem cell , regulator , anaerobic glycolysis , metabolism , metabolic pathway , hematopoietic stem cell , biochemistry , cell cycle , cell , gene
Cellular metabolism is a key regulator of hematopoietic stem cell (HSC) maintenance. HSCs rely on anaerobic glycolysis for energy production to minimize the production of reactive oxygen species and shift toward mitochondrial oxidative phosphorylation upon differentiation. However, increasing evidence has shown that HSCs still maintain a certain level of mitochondrial activity in quiescence, and exhibit high mitochondrial membrane potential, which both support proper HSC function. Since glycolysis and the tricarboxylic acid (TCA) cycle are not directly connected in HSCs, other nutrient pathways, such as amino acid and fatty acid metabolism, generate acetyl‐CoA and provide it to the TCA cycle. In this review, we discuss recent insights into the regulatory roles of cellular metabolism in HSCs. Understanding the metabolic requirements of healthy HSCs is of critical importance to the development of new therapies for hematological disorders.