Open AccessRecommendations for Pregnancy in Rare Inherited Anemias
Author(s) -
Taher Ali T.,
Iolascon Achille,
Matar Charbel F.,
BouFakhredin Rayan,
Franceschi Lucia,
Cappellini Maria Domenica,
Barcellini Wilma,
Russo Roberta,
Andolfo Immacolata,
Tyan Paul,
Gulbis Beatrice,
Aydinok Yesim,
Anagnou Nicholas P.,
Bencaiova Gabriela Amstad,
Tamary Hannah,
Martinez Patricia Aguilar,
Forni Gianluca,
Vindigni Raffaele
Publication year - 2020
Publication title -
hemasphere
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 11
ISSN - 2572-9241
DOI - 10.1097/hs9.0000000000000446
Subject(s) - diamond–blackfan anemia , medicine , thalassemia , pregnancy , hematology , ineffective erythropoiesis , anemia , pediatrics , population , intensive care medicine , rare disease , erythropoiesis , disease , pathology , immunology , genetics , biology , environmental health , ribosome , rna , gene
Rare inherited anemias are a subset of anemias caused by a genetic defect along one of the several stages of erythropoiesis or in different cellular components that affect red blood cell integrity, and thus its lifespan. Due to their low prevalence, several complications on growth and development, and multi‐organ system damage are not yet well defined. Moreover, during the last decade there has been a lack of proper understanding of the impact of rare anemias on maternal and fetal outcomes. In addition, there are no clear‐cut guidelines outlining the pathophysiological trends and management options unique to this special population. Here, we present on behalf of the European Hematology Association, evidence‐ and consensus‐based guidelines, established by an international group of experts in different fields, including hematologists, gynecologists, general practitioners, medical geneticists, and experts in rare inherited anemias from various European countries for standardized and appropriate choice of therapeutic interventions for the management of pregnancy in rare inherited anemias, including Diamond‐Blackfan Anemia, Congenital Dyserythropoietic Anemias, Thalassemia, Sickle Cell Disease, Enzyme deficiency and Red cell membrane disorders.