Open AccessOral Antiplatelet Therapy Administered Upstream to Patients With NSTEMI
Author(s) -
Charles V. Pollack,
W. Frank Peacock,
Durgesh Bhandary,
Steven H. Silber,
Narinder Bhalla,
Sunil V. Rao,
Deborah B. Diercks,
Alex Frost,
Sripal Bangalore,
John F. Heitner,
Charles L. Johnson,
Renato DeRita,
Naeem Khan
Publication year - 2020
Publication title -
critical pathways in cardiology
Language(s) - English
Resource type - Journals
eISSN - 1535-282X
pISSN - 1535-2811
DOI - 10.1097/hpc.0000000000000243
Subject(s) - ticagrelor , medicine , prasugrel , clopidogrel , acute coronary syndrome , cohort , thienopyridine , myocardial infarction , p2y12 , cardiology , emergency medicine
To describe from a noninterventional registry (Utilization of Ticagrelor in the Upstream Setting for Non-ST-Segment Elevation Acute Coronary Syndrome), the short-term ischemic and hemorrhagic outcomes in patients with non-ST elevation myocardial infarction (MI) are managed with a loading dose (LD) of a P2Y12 inhibitor (P2Y12i) given at least 4 hours before diagnostic angiography and delineation of coronary anatomy. Prior data on the effects of such "upstream loading" have been inconsistent.