Open AccessLack of Cellular Inflammation in a Non-human Primate Model of Radiation Nephropathy
Author(s) -
Eric P. Cohen,
Ann M. Farese,
George A. Parker,
Maureen A. Kane,
Thomas J. MacVittie
Publication year - 2020
Publication title -
health physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.357
H-Index - 73
eISSN - 1538-5159
pISSN - 0017-9078
DOI - 10.1097/hp.0000000000001329
Subject(s) - inflammation , radiation injury , medicine , kidney , acute injury , acute kidney injury , radiation exposure , immunology , cancer research , pathology , biology , radiation therapy , surgery , nuclear medicine
Inflammation is commonly cited as a mechanism of delayed effects of acute radiation exposure (DEARE). Confirmation of its presence could provide significant insight to targeted use of treatments or mitigators of DEARE. We sought to quantify the presence of cellular inflammation in kidneys of non-human primates that developed acute and chronic kidney injury after a partial body irradiation exposure. We show herein that cellular inflammation is not found as a component of either acute or chronic kidney injury. Other mechanistic pathways of injury must be sought.