Open AccessTranscriptomics of angiotensin II-induced long noncoding and coding RNAs in endothelial cells
Author(s) -
Shuhan Bu,
Hien Nguyen,
David Michels,
Berk Rasheed,
Sepideh Nikfarjam,
Rohan Singh,
Lynn Wang,
Darshil A Patel,
Shweta Singh,
Mohammad Qadura,
Krishna K. Singh
Publication year - 2022
Publication title -
journal of hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.249
H-Index - 172
eISSN - 1473-5598
pISSN - 0263-6352
DOI - 10.1097/hjh.0000000000003140
Subject(s) - medicine , transcriptome , long non coding rna , computational biology , coding (social sciences) , angiotensin ii , microbiology and biotechnology , genetics , rna , gene expression , gene , biology , receptor , statistics , mathematics
Angiotensin II (Ang II)-induced endothelial dysfunction plays an important role in the pathogenesis of cardiovascular diseases such as systemic hypertension, cardiac hypertrophy and atherosclerosis. Recently, long noncoding RNAs (lncRNAs) have been shown to play an essential role in the pathobiology of cardiovascular diseases; however, the effect of Ang II on lncRNAs and coding RNAs expression in endothelial cells has not been evaluated. Accordingly, we sought to evaluate the expression profiles of lncRNAs and coding RNAs in endothelial cells following treatment with Ang II.