Open AccessEarly renal and vascular damage within the normoalbuminuria condition
Author(s) -
Aránzazu Santiago-Hernández,
Marta Martín-Lorenzo,
Pedro Luis Moreno Martínez,
María Gómez-Serrano,
Juan Antonio López,
Pablo Cannata,
Vanesa Esteban,
Angeles Heredero,
Gonzalo Aldamiz-Echevarría,
Jesús Vázquez,
Gema RuizHurtado,
María G. Barderas,
Julián Segura,
Luis Ruilope,
Gloria Álvarez-Llamas
Publication year - 2021
Publication title -
journal of hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.249
H-Index - 172
eISSN - 1473-5598
pISSN - 0263-6352
DOI - 10.1097/hjh.0000000000002936
Subject(s) - albuminuria , medicine , subclinical infection , endocrinology , kidney , creatinine , renal function
A continuous association between albuminuria and cardiorenal risk exists further below moderately increased albuminuria ranges. If only based in albumin to creatinine ratio (ACR) higher than 30 mg/g, a significant percentage of individuals may be out of the scope for therapeutic management. Despite epidemiological outcomes, the identification of biochemical changes linked to early albuminuria is underexplored, and normoalbuminuric individuals are usually considered at no risk in clinical practice. Here, we aimed to identify early molecular alterations behind albuminuria development.