Open AccessCollecting duct-specific knockout of sphingosine-1-phosphate receptor 1 aggravates DOCA-salt hypertension in mice
Author(s) -
Gaizun Hu,
Qing Zhu,
Weili Wang,
Dengpiao Xie,
Chaoling Chen,
PinLan Li,
Joseph K. Ritter,
Ningjun Li
Publication year - 2021
Publication title -
journal of hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.249
H-Index - 172
eISSN - 1473-5598
pISSN - 0263-6352
DOI - 10.1097/hjh.0000000000002809
Subject(s) - endocrinology , medicine , knockout mouse , s1pr1 , excretion , natriuresis , sodium , wild type , receptor , chemistry , biochemistry , mutant , organic chemistry , vascular endothelial growth factor a , vascular endothelial growth factor , vegf receptors , gene
We have previously reported that renal medullary sphingosine-1-phosphate (S1P) regulates sodium excretion via the S1P type-1 receptor (S1PR1). As S1PR1 is predominantly expressed in collecting ducts (CD), the present study tested the hypothesis that the CD-S1PR1 pathway plays a critical role in sodium excretion and contributes to salt-sensitive hypertension.