Open AccessWild-type p53-induced phosphatase 1 promotes vascular smooth muscle cell proliferation and neointima hyperplasia after vascular injury via p-adenosine 5′-monophosphate-activated protein kinase/mammalian target of rapamycin complex 1 pathway
Author(s) -
Xiongshan Sun,
Shuang Li,
Xueqing Gan,
Chenming Qiu,
Ken Chen,
Haifeng Pei,
Qiang Wang,
De Li,
Xiuchuan Li,
Dachun Yang,
Yongjian Yang
Publication year - 2019
Publication title -
journal of hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.249
H-Index - 172
eISSN - 1473-5598
pISSN - 0263-6352
DOI - 10.1097/hjh.0000000000002159
Subject(s) - neointima , medicine , vascular smooth muscle , adenosine , adenosine monophosphate , protein kinase a , microbiology and biotechnology , kinase , phosphatase , cell growth , smooth muscle , phosphorylation , biochemistry , biology , restenosis , stent
Vascular smooth muscle cell (VSMC) proliferation is a crucial cause of vascular neointima hyperplasia and restenosis, thus limiting the long-term efficacy of percutaneous vascular intervention. We explored the role of wild-type p53-induced phosphatase 1 (Wip1), a potent regulator of tumorigenesis and atherosclerosis, in VSMC proliferation and neointima hyperplasia.