Open AccessImproved renal outcomes after revascularization of the stenotic renal artery in pigs by prior treatment with low-energy extracorporeal shockwave therapy
Author(s) -
Xiao Jun Chen,
Xin Zhang,
Kai Jiang,
James D. Krier,
Xiangyang Zhu,
Amir Lerman,
Lilach O. Lerman
Publication year - 2019
Publication title -
journal of hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.249
H-Index - 172
eISSN - 1473-5598
pISSN - 0263-6352
DOI - 10.1097/hjh.0000000000002158
Subject(s) - medicine , renal artery stenosis , renal function , kidney , revascularization , renal artery , urology , renal blood flow , renovascular hypertension , fibrosis , cardiology , myocardial infarction
Revascularization does not restore renal function in most patients with atherosclerotic renal artery stenosis (RAS), likely because of inflammation and fibrosis within the stenotic kidney. Low-energy shockwave therapy (LE-SWT) stimulates angiogenesis in the stenotic kidney, but its ability to improve renal function and structure after revascularization remains unexplored. We tested the hypothesis that a LE-SWT regimen before percutaneous transluminal renal angioplasty (PTRA) would enable PTRA to restore renal function in hypercholesterolemic pigs with RAS (HC+RAS), and that this would be associated with attenuation of renal inflammation and fibrosis.