Open AccessNeuropeptidase activity in the frontal cortex of Wistar–Kyoto and spontaneously hypertensive rats treated with vasoactive drugs
Author(s) -
Isabel Prieto,
Ana Belén Segarra,
Ana Belén Villarejo,
Marc de Gasparo,
María M Martínez-Cañamero,
Manuel RamírezSánchez
Publication year - 2019
Publication title -
journal of hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.249
H-Index - 172
eISSN - 1473-5598
pISSN - 0263-6352
DOI - 10.1097/hjh.0000000000001884
Subject(s) - medicine , vasoactive , spontaneously hypertensive rat , frontal cortex , pharmacology , endocrinology , blood pressure
Hypertension can lead to mood disorders that may worsen or ameliorate depending on the type of antihypertensive prescribed. Depression is associated with modifications in basal brain asymmetry particularly that of the frontal cortex, which is involved in blood pressure control. Furthermore, different vasoactive drugs may change the brain's asymmetry in a manner that contributes to cognition status. We studied the bilateral activity of several neuropeptidases in frontal cortex as a reflect of the functional status of certain neuropeptides involved in mood.