Open AccessGenetics of dilated cardiomyopathy
Author(s) -
Suet Nee Chen,
Luisa Mestroni,
Matthew R.G. Taylor
Publication year - 2021
Publication title -
current opinion in cardiology/current opinion in cardiology, with evaluated medline
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.826
H-Index - 78
eISSN - 1080-787X
pISSN - 0268-4705
DOI - 10.1097/hco.0000000000000845
Subject(s) - dilated cardiomyopathy , medicine , lmna , pathogenesis , genetics , cardiomyopathy , rna splicing , gene , bioinformatics , mutation , cardiology , biology , rna , heart failure
Dilated cardiomyopathy (DCM), which include genetic and nongenetic forms, is the most common form of cardiomyopathy. DCM is characterized by left ventricular or biventricular dilation with impaired contraction. In the United States, DCM is a burden to healthcare that accounts for approximately 10,000 deaths and 46,000 hospitalizations annually. In this review, we will focus on the genetic forms of DCM and on recent advances in the understanding of cytoskeletal, sarcomeric, desmosomal, nuclear membrane, and RNA binding genes that contribute to the complexity and genetic heterogeneity of DCM.