Open AccessFunctional characterization of long noncoding RNAs
Author(s) -
Joseph B. Moore,
Shizuka Uchida
Publication year - 2020
Publication title -
current opinion in cardiology/current opinion in cardiology, with evaluated medline
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.826
H-Index - 78
eISSN - 1080-787X
pISSN - 0268-4705
DOI - 10.1097/hco.0000000000000725
Subject(s) - malat1 , biology , computational biology , rna , long non coding rna , meg3 , microrna , epigenetics , transcription factor , non coding rna , xist , regulation of gene expression , rna binding protein , gene , genetics , microbiology and biotechnology , x inactivation , x chromosome
Mounting evidence suggests that long noncoding RNAs (lncRNAs) are essential regulators of gene expression. Although few lncRNAs have been the subject of detailed molecular and functional characterization, it is believed that lncRNAs play an important role in tissue homeostasis and development. In fact, gene expression profiling studies reveal lncRNAs are developmentally regulated in a tissue-type and cell-type specific manner. Such findings have brought significant attention to their potential contribution to disease cause. The current review summarizes recent studies of lncRNAs in the heart.