Open AccessA rehabilitation exercise program induces severe bone mineral deficits in estrogen-deficient rats after extended disuse
Author(s) -
Joshua F. Yarrow,
Sean C. McCoy,
J. Andries Ferreira,
Jennifer E. Pingel,
Bryan P. Conrad,
Thomas J. Wronski,
Alyssa Williams,
Stephen E. Borst,
Marybeth Brown
Publication year - 2012
Publication title -
menopause
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.086
H-Index - 103
eISSN - 1530-0374
pISSN - 1072-3714
DOI - 10.1097/gme.0b013e318255657f
Subject(s) - bone mineral , ovariectomized rat , medicine , estrogen , endocrinology , cortical bone , quantitative computed tomography , metaphysis , osteoporosis , anatomy
Both estrogen and mechanical loading regulate bone maintenance. However, mechanical overload seems less effective in enhancing bone mineral density (BMD) in estrogen-deficient women. The aim of this study was to determine whether estradiol (E2) influences early-phase bone adaptations to reambulation (REAMB) and/or rehabilitation exercises after hindlimb unloading (HLU) of ovariectomized rats.