Open AccessEndometrial microbiota from endometrial cancer and paired pericancer tissues in postmenopausal women: differences and clinical relevance
Author(s) -
Jeanne Bouteaud,
Ola Shaltout,
Marie K. Christakis,
Fahmeeda Murtaza,
Wendy Wolfman,
Lindsay Shirreff
Publication year - 2022
Publication title -
menopause
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.086
H-Index - 103
eISSN - 1530-0374
pISSN - 1072-3714
DOI - 10.1097/gme.0000000000002053
Subject(s) - endometrium , medicine , endometrial cancer , prevotella , lactobacillus , microbiome , gynecology , physiology , biology , cancer , bioinformatics , bacteria , genetics
The incidence of postmenopausal endometrial cancer (EC) is rising, and the uterine microbiota has recently been suggested to be an etiology of EC. However, the differences in microbiota profiles in paired EC and the adjacent non-EC endometrium, and the functional microbiota of clinical relevance remain largely unknown. Therefore, we examined the differences in microbiota profiles between EC and non-EC endometrium and investigated their clinical relevance to EC.