Open AccessThe challenging screen detection of ovarian cancer in BRCA mutation carriers adhering to a 6-month follow-up program: results from a 6-years surveillance
Author(s) -
Giovanni Grandi,
Federica Fiocchi,
Laura Cortesi,
Angela Toss,
F. Boselli,
Margaret Sammarini,
Giovanna Sighinolfi,
Fabio Facchinetti
Publication year - 2021
Publication title -
menopause
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.086
H-Index - 103
eISSN - 1530-0374
pISSN - 1072-3714
DOI - 10.1097/gme.0000000000001883
Subject(s) - medicine , ovarian cancer , brca mutation , gynecology , breast cancer , cancer , incidence (geometry) , cohort , genetic testing , concomitant , prospective cohort study , obstetrics , physics , optics
Approximately 25% of ovarian cancer (OC) cases are related to an inherited predisposition. Genetic mutations for the oncosuppressor genes BRCA1 and 2 have the best-known linkage to a higher incidence of OC and breast cancer, in approximately 70% to 80% of hereditary OC cases. To provide the first comprehensive clinical description of screen-detected (SD) OCs during a 6-years surveillance of a cohort of young BRCA carriers and carriers who refuse risk-reducing salpingo-oophorectomy.