Open AccessTreatment with a dual amylin and calcitonin receptor agonist improves metabolic health in an old, obese, and ovariectomized rat model
Author(s) -
Anna Katri,
D. Reker,
Morten A. Karsdal,
AnneChristine BayJensen,
Kim Henriksen
Publication year - 2021
Publication title -
menopause
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.086
H-Index - 103
eISSN - 1530-0374
pISSN - 1072-3714
DOI - 10.1097/gme.0000000000001722
Subject(s) - amylin , medicine , endocrinology , insulin resistance , calcitonin receptor , ovariectomized rat , menopause , obesity , calcitonin , agonist , insulin , hormone , receptor , calcitonin gene related peptide , neuropeptide , islet
Menopause is often characterized by detrimental metabolic changes, such as obesity, insulin resistance, and impaired glucose tolerance, often requiring treatment. KeyBioscience Peptides (KBPs) are Dual Amylin and Calcitonin Receptor Agonists which have shown promising metabolic effects in rats. The objective of this study was to investigate the in vivo effect of KBP on the metabolic health in a model driven by unhealthy diet, age, and menopause.