Open AccessHigh-density lipoprotein cholesterol and arterial calcification in midlife women: the contribution of estradiol and C-reactive protein
Author(s) -
Gretchen Swabe,
Karen A. Matthews,
Maria M. Brooks,
İmke Janssen,
Norman Wang,
Samar R. El Khoudary
Publication year - 2020
Publication title -
menopause
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.086
H-Index - 103
eISSN - 1530-0374
pISSN - 1072-3714
DOI - 10.1097/gme.0000000000001706
Subject(s) - medicine , odds ratio , quartile , c reactive protein , endocrinology , menopause , cholesterol , high density lipoprotein , cardiology , confidence interval , inflammation
Studies suggest a reversal in the protective association of high-density lipoprotein cholesterol (HDL-C) and cardiovascular disease in women traversing menopause. Decreasing estrogen levels during the transition, as well as inflammation, may explain this reversal. We tested whether either estradiol or C-reactive protein (CRP) concentrations modified the association of HDL-C with aortic (AC) or coronary artery calcification (CAC).