Open AccessGenetic polymorphisms in collagen-related genes are associated with pelvic organ prolapse
Author(s) -
Lei Li,
Zhijing Sun,
Juan Chen,
Ye Zhang,
Honghui Shi,
Lan Zhu
Publication year - 2019
Publication title -
menopause
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.086
H-Index - 103
eISSN - 1530-0374
pISSN - 1072-3714
DOI - 10.1097/gme.0000000000001448
Subject(s) - single nucleotide polymorphism , snp , medicine , logistic regression , genetic association , candidate gene , gynecology , genotype , genetics , gene , biology
Pelvic organ prolapse (POP) is a common health issue that has a profound negative influence on women's quality of life. Genetic susceptibility to POP has been increasingly investigated. In this study, we assessed the single-nucleotide polymorphisms (SNPs) of six collagen-related genes (COL14A1, COL5A1, COL4A2, COL3A1, COL1A1, and COL18A1) and the genetic association with POP in Chinese women.