Open AccessHigh Tacrolimus Intrapatient Variability and Subtherapeutic Immunosuppression are Associated With Adverse Kidney Transplant Outcomes
Author(s) -
Aleixandra Mendoza Rojas,
Dennis A. Hesselink,
Nicole M. van Besouw,
M. Dieterich,
P de Kuiper,
Carla C. Baan,
Teun van Gelder
Publication year - 2022
Publication title -
therapeutic drug monitoring
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.649
H-Index - 93
eISSN - 1536-3694
pISSN - 0163-4356
DOI - 10.1097/ftd.0000000000000955
Subject(s) - tacrolimus , immunosuppression , medicine , transplantation , kidney transplantation , mycophenolic acid , odds ratio , immunology , gastroenterology
Kidney transplant recipients with high intrapatient variability (IPV) in tacrolimus (Tac) exposure experience more rejection and reduced graft survival. To understand the underlying pathophysiology of this association, the authors investigated whether patients with high tacrolimus IPV have a more activated immune system than patients with low IPV. In addition, exposure to tacrolimus and mycophenolic acid (MPA) was studied in relation to rejection and graft survival.