Open AccessValidation and Clinical Application of a Liquid Chromatography–Ultraviolet Detection Method to Quantify Dolutegravir in Dried Blood Spots
Author(s) -
Abdulafeez Akinloye,
Oluwasegun Eniayewu,
Babatunde Ayodeji Adeagbo,
Oluseye O. Bolaji,
Adeniyi Olagunju
Publication year - 2022
Publication title -
therapeutic drug monitoring
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.649
H-Index - 93
eISSN - 1536-3694
pISSN - 0163-4356
DOI - 10.1097/ftd.0000000000000929
Subject(s) - dolutegravir , chromatography , dried blood spot , pharmacokinetics , therapeutic drug monitoring , bioanalysis , chemistry , whole blood , antiretroviral therapy , human immunodeficiency virus (hiv) , medicine , pharmacology , viral load , surgery , family medicine
Dolutegravir is currently the preferred component of first-line antiretroviral therapy. To facilitate clinical pharmacology studies in key populations, quantitative analytical methods compatible with microsampling and adaptable to resource-limited settings are desirable. The authors developed and validated a liquid chromatography-ultraviolet detection method to quantify dolutegravir in dried blood spots (DBS).