Open AccessTacrolimus Measured in Capillary Volumetric Microsamples in Pediatric Patients—A Cross-Validation Study
Author(s) -
Ingvild Andrea Kindem,
Anna Bjerre,
Anders Åsberg,
Karsten Midtvedt,
Stein Bergan,
Nils Tore Vethe
Publication year - 2021
Publication title -
therapeutic drug monitoring
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.649
H-Index - 93
eISSN - 1536-3694
pISSN - 0163-4356
DOI - 10.1097/ftd.0000000000000873
Subject(s) - venipuncture , medicine , venous blood , tacrolimus , confidence interval , dosing , mean difference , urology , surgery , transplantation
Therapeutic drug monitoring of tacrolimus (Tac) is mandatory in solid organ transplant (SOT) recipients. Finger-prick microsampling is more flexible and tolerable during the therapeutic drug monitoring of tacrolimus and has been shown to be applicable in adult SOT recipients. In this study, a previously validated method applying volumetric absorptive microsampling (VAMS) to measure Tac in adults was cross-validated in a pediatric population.