Open AccessValidation of a Capillary Dry Blood Sample MITRA-Based Assay for the Quantitative Determination of Systemic Tacrolimus Concentrations in Transplant Recipients
Author(s) -
Nasrullah Undre,
I. M. P. Dawson,
Varuna Aluvihare,
Nassim Kamar,
Faouzi Saliba,
Nicholas Torpey,
Swapneel Anaokar,
Gbenga Kazeem,
Imran Hussain
Publication year - 2020
Publication title -
therapeutic drug monitoring
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.649
H-Index - 93
eISSN - 1536-3694
pISSN - 0163-4356
DOI - 10.1097/ftd.0000000000000847
Subject(s) - tacrolimus , venipuncture , medicine , venous blood , therapeutic drug monitoring , coefficient of variation , blood sampling , whole blood , pharmacokinetics , urology , chemistry , chromatography , transplantation , surgery
Tacrolimus is a narrow therapeutic index medication, which requires therapeutic drug monitoring to optimize dosing based on systemic exposure. MITRA microsampling offers a convenient, minimally invasive approach for the collection of capillary blood samples from a finger prick versus conventional venous blood sampling for quantitation of tacrolimus blood concentrations. However, the suitability of MITRA microsampling for the determination of tacrolimus concentrations requires assessment in clinical settings.