Open AccessQuantitation of Tacrolimus in Human Whole Blood Samples Using the MITRA Microsampling Device
Author(s) -
Nasrullah Undre,
Imran Hussain,
John Meijer,
Johannes Stanta,
Gordon Swan,
I. M. P. Dawson
Publication year - 2020
Publication title -
therapeutic drug monitoring
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.649
H-Index - 93
eISSN - 1536-3694
pISSN - 0163-4356
DOI - 10.1097/ftd.0000000000000833
Subject(s) - bioanalysis , chromatography , tacrolimus , therapeutic drug monitoring , whole blood , chemistry , analyte , hematocrit , liquid chromatography–mass spectrometry , pharmacology , medicine , pharmacokinetics , mass spectrometry , transplantation
The calcineurin inhibitor tacrolimus is a narrow therapeutic index medication, which requires therapeutic drug monitoring to optimize dose on the basis of systemic exposure. MITRA microsampling offers a minimally invasive approach for the collection of capillary blood samples from a fingerprick as an alternative to conventional venous blood sampling for quantitation of tacrolimus concentrations.