Open AccessPopulation Pharmacokinetic Modeling of Vancomycin in Thai Patients With Heterogeneous and Unstable Renal Function
Author(s) -
Siriluk Jaisue,
Cholatip Pongsakul,
David Z. D’Argenio,
Pakawadee Sermsappasuk
Publication year - 2020
Publication title -
therapeutic drug monitoring
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.649
H-Index - 93
eISSN - 1536-3694
pISSN - 0163-4356
DOI - 10.1097/ftd.0000000000000801
Subject(s) - renal function , pharmacokinetics , medicine , vancomycin , population , urology , therapeutic drug monitoring , surgery , biology , environmental health , bacteria , genetics , staphylococcus aureus
Vancomycin is widely used to treat gram-positive bacterial infections. However, given significant interpatient variability in its pharmacokinetics, maintaining plasma concentrations is difficult within its characteristically narrow therapeutic window. This is especially challenging in patients with unstable renal function. Thus, the aim of this study was to develop a population pharmacokinetic model for vancomycin that is suitable for Thai patients with variable renal functions, including those with unstable renal function.