Open AccessA Novel Correction Equation Avoids High-Magnitude Errors in Interpreting Therapeutic Drug Monitoring of Phenytoin Among Critically Ill Patients
Author(s) -
Megan E. Barra,
Kristy M. Phillips,
David Y. Chung,
Eric S. Rosenthal
Publication year - 2020
Publication title -
therapeutic drug monitoring
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.649
H-Index - 93
eISSN - 1536-3694
pISSN - 0163-4356
DOI - 10.1097/ftd.0000000000000739
Subject(s) - phenytoin , medicine , intensive care unit , therapeutic drug monitoring , cohort , population , critically ill , hypoalbuminemia , anesthesia , therapeutic index , cohort study , pharmacokinetics , drug , epilepsy , pharmacology , environmental health , psychiatry
Phenytoin has a narrow therapeutic index and the potential of under-treatment or toxicity. Available equations are used to correct for the impact of hypoalbuminemia on unbound (free) phenytoin levels. The authors aimed to determine the accuracy of equations used to estimate free phenytoin in hospitalized patients and assess the impact of using additional clinical data.