Open AccessPharmacokinetics of Doripenem in Healthy Koreans and Monte Carlo Simulations to Explore Optimal Dosage Regimens in Patients With Normal and Enhanced Renal Function
Author(s) -
So Won Kim,
Sangmin Choe,
Dong Jin Kim,
Dae Young Zang,
Donghwan Lee
Publication year - 2018
Publication title -
therapeutic drug monitoring
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.649
H-Index - 93
eISSN - 1536-3694
pISSN - 0163-4356
DOI - 10.1097/ftd.0000000000000528
Subject(s) - doripenem , pharmacokinetics , renal function , medicine , dosing , population , urology , volume of distribution , pharmacology , chemistry , antibiotics , biochemistry , environmental health , antibiotic resistance , imipenem
Dose adjustment is often required in patients with normal or enhanced renal function. The aim of this study is to investigate the pharmacokinetic (PK) properties of doripenem and explore optimal dosing regimens in patients with normal or enhanced renal function according to various minimum inhibitory concentrations (MICs).