Open AccessLimited contribution of common genetic variants to risk for liver injury due to a variety of drugs
Author(s) -
Thomas Urban,
Yufeng Shen,
Andrew Stolz,
Naga Chalasani,
Robert J. Fontana,
James Rochon,
Dongliang Ge,
Kevin V. Shianna,
Ann K. Daly,
M. Isabel Lucena,
Matthew R. Nelson,
Mariam Molokhia,
Guruprasad P. Aithal,
Aris Floratos,
Itsik Pe’er,
José Serrano,
Herbert L. Bonkovsky,
Timothy J. Davern,
William M. Lee,
Victor J. Navarro,
Jayant A. Talwalkar,
David B. Goldstein,
Paul B. Watkins
Publication year - 2012
Publication title -
pharmacogenetics and genomics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.579
H-Index - 140
eISSN - 1744-6880
pISSN - 1744-6872
DOI - 10.1097/fpc.0b013e3283589a76
Subject(s) - genome wide association study , 1000 genomes project , pharmacogenetics , population , medicine , single nucleotide polymorphism , biology , genetic association , genetics , bioinformatics , genotype , gene , environmental health
Drug-induced liver injury (DILI) is a serious adverse drug event that is suspected to have a heritable component. We carried out a genome-wide association study of 783 individuals of European ancestry who experienced DILI due to more than 200 implicated drugs.