Open AccessHistone acetylation at the sulfotransferase 1a1 gene is associated with its hepatic expression in normal aging
Author(s) -
Mohamad M. Kronfol,
Sara Abudahab,
Mikhail G. Dozmorov,
Fay M. Jahr,
Matthew S. Halquist,
MaryPeace McRae,
Dayanjan S. Wijesinghe,
Elvin Price,
Patricia W. Slattum,
Joseph L. McClay
Publication year - 2021
Publication title -
pharmacogenetics and genomics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.579
H-Index - 140
eISSN - 1744-6880
pISSN - 1744-6872
DOI - 10.1097/fpc.0000000000000443
Subject(s) - epigenetics , histone , epigenome , acetylation , dna methylation , biology , epigenomics , regulation of gene expression , gene expression , methylation , genetics , gene
Phase II drug metabolism is poorly studied in advanced age and older adults may exhibit significant variability in their expression of phase II enzymes. We hypothesized that age-related changes to epigenetic regulation of genes involved in phase II drug metabolism may contribute to these effects.