Open AccessZNF423 modulates the AMP-activated protein kinase pathway and metformin response in a single nucleotide polymorphisms, estrogen and selective estrogen receptor modulator dependent fashion
Author(s) -
Sisi Qin,
James N. Ingle,
Wootae Kim,
Huanyao Gao,
Richard M. Weinshilboum,
Liewei Wang
Publication year - 2021
Publication title -
pharmacogenetics and genomics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.579
H-Index - 140
eISSN - 1744-6880
pISSN - 1744-6872
DOI - 10.1097/fpc.0000000000000435
Subject(s) - selective estrogen receptor modulator , single nucleotide polymorphism , ampk , biology , estrogen receptor , metformin , tamoxifen , protein kinase a , cancer research , kinase , microbiology and biotechnology , genetics , gene , breast cancer , cancer , endocrinology , genotype , diabetes mellitus
We previously discovered that the single nucleotide polymorphisms (SNP) rs9940645 in the ZNF423 gene regulate ZNF423 expression and serve as a potential biomarker for response to selective estrogen receptor modulators (SERMs). Here we explored pathways involved in ZNF423-mediated SERMs response and drugs that potentially sensitize SERMs.