Open AccessThe Effects of Low-Dose Simvastatin and Ezetimibe Compared to High-Dose Simvastatin Alone on Post-Fat Load Endothelial Function in Patients With Metabolic Syndrome: A Randomized Double-Blind Crossover Trial
Author(s) -
Jobien K. Olijhoek,
Gideon R. Hajer,
Yolanda van der Graaf,
Geesje M. DallingaThie,
Frank L.J. Visseren
Publication year - 2008
Publication title -
journal of cardiovascular pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.762
H-Index - 100
eISSN - 1533-4023
pISSN - 0160-2446
DOI - 10.1097/fjc.0b013e31817ffe76
Subject(s) - simvastatin , ezetimibe , medicine , metabolic syndrome , endocrinology , crossover study , insulin resistance , combination therapy , postprandial , hyperlipidemia , endothelial dysfunction , cholesterol , urology , insulin , diabetes mellitus , placebo , alternative medicine , pathology
Insulin resistance is associated with postprandial hyperlipidemia and endothelial dysfunction. Patients with metabolic syndrome, characterized by insulin resistance, are at increased cardiovascular risk. The aim of the present study was to investigate whether a similar low-density lipoprotein cholesterol (LDL-c) reduction with combination therapy of low-dose simvastatin and ezetimibe or with high-dose simvastatin alone has similar effects on (post-fat load) endothelial function.