Open AccessFasudil Attenuates Myocardial Fibrosis in Association With Inhibition of Monocyte/Macrophage Infiltration in the Heart of DOCA/Salt Hypertensive Rats
Author(s) -
Kazuhiro Ishimaru,
Hitoshi Ueno,
Satoshi Kagitani,
Daisuke Takabayashi,
Masanobu Takata,
Hiroshi Inoue
Publication year - 2007
Publication title -
journal of cardiovascular pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.762
H-Index - 100
eISSN - 1533-4023
pISSN - 0160-2446
DOI - 10.1097/fjc.0b013e318064f150
Subject(s) - fasudil , medicine , endocrinology , monocyte , fibrosis , hydroxyproline , myocardial fibrosis , infiltration (hvac) , chemistry , rho associated protein kinase , kinase , biochemistry , physics , thermodynamics
To determine the effects of fasudil, a Rho-kinase inhibitor, on mineralocorticoid-induced myocardial remodeling, we investigated whether fasudil would suppress myocardial fibrosis and inflammation in deoxycorticosterone-acetate (DOCA)/salt hypertensive rats.